Art Meets Science: Best of Data Visualization
By Liz King for 410BC

This month’s best of data visualization was published in Nature last year in April of 2013. Karl Deisseroth and colleagues developed a novel method called CLARITY that turns the brain transparent to allow for the visualization of neuronal networks.

Traditional methods for visualizing neuronal networks are tedious. The brain must be sliced very finely and each slice individually analyzed in order to generate a composite image. The CLARITY method allows for the rapid visualization of neuronal networks in the whole brain and thus may provide insight into how neuronal networks are rewired in disease states.

In the first step of the CLARITY process, the brain is infused with acrylamide. When heated, acrylamide creates a mesh matrix that freezes the cell contents (proteins, nucleic acids, and other molecules) in place. Next, the detergent sodium dodecyl sulfate (SDS) is applied to break down the lipid bilayer that normally surrounds the cell and obstructs the view of the cell contents. Once these lipids are washed away, fluorescently-labeled antibodies can be added to identify specific neuronal proteins within the brain.

In the beautiful video linked below, you can see the CLARITY method in action. Here, the method is used to visualize fluorescently-labeled neurons in whole mouse brain. The method is also used to trace the path of a single neuron in a slice of autopsied human brain from a patient with Autism.

YouTube Link:


Today is 410 BC’s 6th birthday. It’s hard to believe we’ve made it this far and are still going strong. We started this business in a dorm room our 1st year of college, selling tees on campus and then on consignment in some local shops. We’ve come a long way since then. There have been many challenges and difficult times. We’ve faced financial strains, as many small businesses do. At one point we almost closed the business, but we kept going. We invested a lot of money from day jobs into the brand, refusing to give up. The reason we are here today is because of our customers and all of the people who have supported us over the years. The wonderful artists we work with, our friends, the amazing bands and musicians who have worn our shirts, the people who told their friends about us, blogged about us, or liked something on our facebook page. You are the reason we are still in business.

We feel very fortunate to still be in business 6 years later. Recently we found ourselves asking, what more can we do? How can we give back more of what we have received? One thing we have always done since starting 410 BC is we’ve had select products that donate money to non-profit organizations and important causes. We’ve loved being able to do this, but previously it was always limited to specific limited edition shirts. We’ve decided to change this. From now on, all new shirts will be donating a minimum of 25% of the proceeds to a cause. Every time you buy from 410BC you will be supporting something important. Our tees will remain limited edition and we plan on supporting a range of different charities.

In honor of our birthday, we would like to ask our friends and supporters to take the time to spread the word about 410BC, so we can continue to thrive. Most of our sales come from social media, so anything you can do makes a huge difference.

We have a very exciting year ahead of us with many new products and changes as we strive to improve the brand and make a positive impact. The last 6 years have been an amazing journey. Thank you all for making this possible.


The 410 BC Team



Hi everyone,

Our friend’s dog is very sick. The surgery to save his life is cost prohibitive for our friend, so she is raising money through gofundme.

If you can donate any amount it is greatly appreciated! If not please consider sharing this link with others. Thank you!


Maury’s Story:

“One day I was online and I came across an ad for Be Humane Society in Arkansas. I clicked on it and there was Maury, 2lbs, the runt of the litter with mange and a grade 3 heart murmur, too small and sick to go to a pet store. His fate was dim. It was love at first sight. I contacted them for information and before I knew it $100 plans were arranged for Maury to take a puppy bus from Arkansas to New York. Halfway through the trip Maury fell ill due to a low glucose level and had to be rushed to a hospital in Virginia. Being the survivor he is, Maury made it through and eventually arrived in New York to meet his mommy and new family, including his current BFF, a Chihuahua named Mia. With love, proper care, nutrition and medication we nursed Maury back to a relatively healthy, extremely happy dog. Today Maury is four years old. He is smart, silly and clever with an amazing personality and he is the love of my life.

I’m humbly asking my fellow dog lovers for help, as Maury is diagnosed with severe pulmonic stenosis. He was never eligible for pet insurance due to his heart murmur so I’ve paid everything out of pocket, including numerous echocardiograms and Cardiologist visits. At this time our cardiologist recommended Maury have a balloon valvuloplasty to treat his pulmonic stenosis and will save his life at the cost of $4,500. I am a social worker with numerous bills of my own including substantial debt acquired from treating Maurys pre-existing conditions. Any help or assistance would be greatly appreciated towards his surgery to ensure the longevity of his life, so he can continue to bring joy and happiness into my world and to everyone who knows him.

I thank you from the bottom of my heart in advance for any contribution big or small. Thank you and God bless you for your compassion in doing whatever you can to help my Maury survive. In my book, you are now considered a part of our family and I will be forever grateful for your generosity and well wishes. Thank you for your time and consideration.”


We have re-stocked the 410 BC Salvation tee shirt

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Anatomy of the heart tee available now in the Anatomist Apparel store

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Limited edition 410BC tee shirt – only 50 prints in total!




Nathan Morris is a maker.
Reared in an eloquent and rural city in the foothills of the blue ridge mountains, Nathan was born of a forest ranger and an elementary school teacher. Perhaps that would explain his relentless emphasis on ‘never growing up’ and his deep admiration of nature. In his youth, he spent his days and nights wading in imperturbable swamps, floating down streams, and hiking in the mountains. To control his insatiable desire to capture the moments fleeting from his youth, he began photographing his surroundings and explicitly writing as much as he could disinter from his soul. After graduating high school in Jacksonville, Alabama, he mustered the energy to defeat the prerequisites and earn a degree from Troy University in Communications and Photography.  Oddly enough, the diplomas led him into the wonderful world of self-employment, advertising and finally into the print and design industry.
Today, he spends his days as a production manager for a print shop, and his nights with his daughter, Marti Sue. Any spare time is spent writing, designing and editing photographs.
All the while, Nathan is currently sharing his quaint house, on a quiet street in Montgomery, Alabama with his daughter, his Himalayan feline Zula, a Russian Spurred Tortoise named Chomper and a Penny June, the Border Collie.


Much thanks to Joey Howell for doing this interview with us! Be sure to check out his website and his online store

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1. How did you get into graphic design? Did you go to school for it, or are you self-taught

I got into graphic design in ’09.. Before then I had always been drawing and trying to perfect and find my style. At the time I was doing a lot of work mainly for bands, trying to get my art printed on shirts or buttons or whatever really. When I got my first design printed I was hooked! I thought it was the coolest thing and this only motivated me to keep creating. I just kept doing more work for bands and eventually people started to come to me for work.. I have never taken class for graphic design – everything I’ve learned I have taught myself through trial and error. It’s been a fun ride so far but eventually I’d like to take an art class and see if I could get anything out it.. we’ll see though.

2. What’s the best piece of advice you could give to someone wanting to go into art and design?

Have fun with it! make what you would like to see on shirts, boards etc.. Also be aware of the styles there are that could suit you.. dig deep and find some favorite artists.. also I’d suggest going for the style that you can be most creative in.

3. What are you favorite types of designs or your favorite themes to work with?

It might sound weird because a lot of my designs are really detailed and have a lot of bright colors but I really like simplistic type designs a lot like the ones you see on:

I also really like the artist: Grant Yansura.. He’s a film maker who really gets creative incorporating drawings into his videos.
My personal favorite themes to draw and work with are themes involving space and the ocean! I really enjoy drawing crazy looking space creatures and underwater dwellers. The ocean and space are such wide open mysterious places.. it gets the creative gears in my head moving.

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4. Who or what inspires you?

A lot of different people inspire me.. I’d have to say the three main artists who inspire me the most are:

1. Rod Serling (Writer and creator of The Twilight Zone.. I’ve always loved how out there he could get with his stories and charecters but in the end the characters and creatures we’d watch on screen would somehow relate to us and the struggles of life. creepy and wholesome at the same time
2. Charlie Immer (Charlie uses a lot of bright colors like myself and I like to see his different color schemes)
3. Justin Guthrie (Justin is a favorite photographer of mine.. he captures life in a different and strange perspective.. I’m always inspired by his work)

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5. Who are some of your favorite artists?

1.Chad Lenjer

2. Nico Holderbaum
3. Charlie Immer
4.Rod Serling

5.Mitchell Davis

6. What is your favorite design that you’ve made so far?

That’d have to be my piece “Breathing In a New Mentality” I did it on wood using black ink and white acrylic.

7. If you could be anywhere in 10 years, where would you be?

I’d want to be around artists and people that would be constantly inspiring me to create new things all the time!




We are very excited to announce a new tee design that we are currently printing and will be available for purchase in the store soon.


This tee was designed by Joey Howell.

We are also happy to announce that we will be donating 100% of the proceeds from the sale of this tee shirt to the Amplify Education Project – a non-profit that offers free tutoring and admissions counseling to students from underserved communities.

We would not be able to do this without Joey’s generosity. Please check out his site, he has an amazing portfolio –

We will also be featuring an interview with him soon. In the meantime, here’s his artist’s Bio:

“My name’s Joey Howell.. I started graphic design in ’09 working for mostly bands up until 2011 when I started working for more skateboarding type brands. I did work for Josh Harmonies Music project (toy machine pro), sk8rats, ripndip, Daylando Media, Wub wheels and a bunch more.. aside from my client work, I love drawing creatures.. at a young age I was drawn into scary movies and watched a lot of The Twilight Zone as a kid which I felt like helped me a lot with some of my pieces. so mixing my love for skateboarding and drawing turned out like this.”


Hey everyone!

We are still looking for people who are interested in contributing content to the 410 BC blog.
This is not a paid position, but it is an opportunity to gain experience and exposure. It is also a great resume booster.

You will also have the opportunity to receive free 410 BC products.

If you are interested, please send us an email at